Material and methods This retrospective study included consecutive clinical stage IV colon adenocarcinoma patients who underwent c-Met inhibitor primary tumour surgery after receiving preoperative chemotherapy
at our center, between July 1st, 2001 and September 30th, 2010. Study protocol, treatment scheme and follow-up Initial clinical staging was performed through a colonoscopy with tumor biopsies, tumor markers and computed tomography (CT). In some cases diagnosis was supplemented with positron emission tomography (PET) or liver magnetic resonance image (MRI). Exclusion criteria included tumors within 15 cm of the anal verge, judged by sigmoidoscopy, or those below the level of the sacral promontory, judged by imaging methods. Inhibitors,research,lifescience,medical Patients with bleeding or obstruction underwent surgical treatment and they were not included in this study. Patients received different schemes of preoperative chemotherapy based on FOLFIRI (12), XELOXIRI (13) or XELOX plus Inhibitors,research,lifescience,medical cetuximab regimen (14). Patients were re-staged at the end of chemotherapy and before surgery to value tumor response and determine surgical treatment feasibility. Inhibitors,research,lifescience,medical After completing chemotherapy, patients were subjected to radical excision of the primary tumor after four weeks from the end of chemotherapy. Occasionally, liver surgery was performed during the same surgical procedure. Postoperative complications were defined as any clinical condition that required prolonged hospital stay
or any deviation from the normal postoperative course. Operative mortality was stated as death within the first 30 days postoperative or during hospital admission after the surgical procedure. It was tried to minimize risk of infection, so maintenance of venous accesses or bladder catheters was valued on a daily basis. Furthermore, antithrombotic prophylaxis was accomplished Inhibitors,research,lifescience,medical by using low molecular weight heparin, pneumatic compression
boots during the operation and compression stockings. Early ambulation and respiratory physiotherapy was encouraged. Nasogastric tube Inhibitors,research,lifescience,medical and drainage systems were reserved for selected cases, trying to restrict their usage. Statistical methods Patient data were obtained from the medical records. The incidence of complications was calculated for the entire population. Values are expressed as medians with range in quantitative variables, or as percentages of the group of origin in categorical Calpain variables. All statistical analyses were performed using SPSS software (version 15.0, SPSS Inc., Chicago, IL, USA). Results Between July 1, 2001 and September 30, 2010, 67 patients went through surgical excision of the primary tumour after receiving chemotherapy for stage IV colon cancer. Table 1 shows baseline patient characteristics. All patients were affected with liver metastasis, with 76.1% (n=51) of them affecting both lobes. Furthermore, 29.8% (n=20) of them had metastasis in additional organs. The mean carcinoembryonic antigen (CEA) at the moment of initial diagnosis was 107.5 ng/mL.