The conditions (concentrations of sodium sulfite solution, reacti

The conditions (concentrations of sodium sulfite solution, reacting time and modified flow rate) of sulfonation were optimized. The hydrodynamic and chromatographic performances were estimated. Coupled with a conductivity detector, a capillary ion chromatography system was set up with the prepared column. Finally, the resultant column was used for the separations of five common univalent cations (Li+, Na+, NH4+, K+ and Cs+) using methanesulfonic acid as the eluent and four divalent cations (Mg2+, Ca2+, Sr2+ and Ba2+) by non-suppressed

capillary ion chromatography; the chromatographic Mizoribine parameters were further researched.”
“Background/Aims: Characteristics of intraductal papillary mucinous neoplasms of pancreas (IPMN) have been clarified by a worldwide survey and meeting. However, the malignant behavior or prognosis of the disease is not always uniform.\n\nMethodology: We examined the clinicopathologic demographics, surgical records and outcome according to degree of histologic malignancy in 18 IPMN patients between

1994 and 2006.\n\nResults: Main duct type was observed in 3 patients, branch duct type in 6, and mixed type in 9. Eight of 18 patients (44.4%) had other malignancies, and other synchronous tumors were observed in the adenoma group. CA 19-9 was increased in invasive carcinomas. The size of the main pancreatic duct and cysts were not correlated with degree of malignancy. Mural nodules were more frequently observed in minimally invasive and invasive carcinomas. Segmental resection or observation was selected in the adenoma group; however, NCT-501 in vivo combined resection of main vessels was performed in invasive carcinoma groups. Although 3 of 5 patients with invasive carcinomas had a recurrence and poor patient prognosis, recurrence was not observed in other groups.\n\nConclusions: Surgical results for IPMN were satisfactory; however, it is necessary to determine

the operative indication before the carcinoma becomes invasive as such lesions have a poor prognosis.”
“The aim of this study was to quantify the dynamic response of locomotion to the first oral levodopa administration of the day in patients with JQ-EZ-05 datasheet fluctuating Parkinson’s disease (PD). Stride length, walking speed, cadence and gait variability were measured with an ambulatory gait monitor in 13 PD patients (8 males) with a clinical history of motor fluctuations. The Unified Parkinson’s Disease Rating Scale (UPDRS) gait score (part 29) was also determined by a movement disorders specialist from video recordings. Subjects arrived in the morning in an ‘off’ state (no PD medication) and walked for a maximum length of 100 m. They then took their usual morning dose of oral levodopa and repeated the walking task at 13 min intervals (on average) over a 90 min period.

Average radiation dose with CT examinations was 1 mSv Of the pos

Average radiation dose with CT examinations was 1 mSv. Of the postoperative nonsubluxated hips (n = 30 for CT and n = 37 for MRI), CT demonstrated a sensitivity of 100% and a specificity of 96%, whereas MRI exhibited a sensitivity of 100% and a specificity of 100%. Of the postoperative subluxated

hips, 66.7% spontaneously reduced, 22.2% remained subluxated, and 11.1% redislocated.\n\nConclusions: This is the first study to compare these imaging modalities in the evaluation of hip reduction in DDH. This study affirms MRI as an alternative selleck to CT scan. The sensitivity and specificity of both modalities appears excellent. Similar to other studies, a large percentage of subluxated hips in both groups reduce without additional surgical intervention.\n\nLevel of Evidence: Diagnostic level II.”
“Objective: Currently, human chorionic gonadotropin (hCG) follow-up after evacuation of hydatidiform moles is essential

to identify patients requiring chemotherapeutic treatment for gestational trophoblastic neoplasia (GTN). We propose a model based on linear regression of postevacuation serum hCG concentrations for the prediction of GTN. Methods: One hundred thirteen patients with at least 3 AL3818 serum samples from days 7 to 28 after evacuation were selected from the Dutch Central Registry for Hydatidiform Moles (1994-2009). The slopes of the linear regression lines of the first 3 log-transformed serum hCG and free beta-hCG values were calculated. Receiver operating characteristic curves were constructed to calculate areas under curve (AUCs). Results: The slope of the hCG regression line showed an AUC of 0.906 (95% confidence interval, 0.845-0.967). Gestational trophoblastic neoplasia could be predicted in 52% of patients with GTN at 97.5% specificity (cutoff, -0.020). Twenty-one percent of patients with GTN

could be predicted before diagnosis according to the International Federation of Gynecology and Obstetrics 2000 criteria. The slope of free beta-hCG showed an AUC of 0.844 (95% confidence interval, 0.752-0.935), 69% sensitivity at 97.5% specificity, and 38% of patients with GTN could be predicted before diagnosis according to the International Federation of Gynecology and Obstetrics criteria. Conclusions: The slope of the linear regression line of hCG proved to be a good test to discriminate between patients who will achieve spontaneous disease remission and patients selleck screening library developing GTN. The slope of free beta-hCG seems to be a better predictor for GTN than the slope of hCG. Although this model needs further validation for different assays, it seems a promising way to predict the more aggressive cases of GTN.”
“High accuracy non-relativistic quantum chemical calculations of the ground state energies and wave-functions of symmetric three-particle Coulomb systems of the form m(1)(+/-)m(2)(+/-)m(3)(-/+), m(1) = m(2), are calculated using an efficient and effective series solution method in a triple orthogonal Laguerre basis set.

05) It also increased

05). It also increased Selleckchem Napabucasin PI3K (p85) and Akt1 expression at the mRNA and protein levels in the hearts of the rats with DCM, with a dose-response relationship. An eight-week treatment using CEPO, in comparison

with a four-week protocol, marginally increased PI3K (p85) and Akt1 expression, and did not demonstrate significant benefit. The study indicated that CEPO protects against DCM, without markedly affecting erythropoiesis, and that the activation of PI3K/Akt may be a key mechanism in the protection conferred by CEPO.”
“Epitaxial CoFe2O4 (CFO) films with different thicknesses (6-240 nm) were fabricated on (001) SrTiO3 substrates by reactive cosputtering. Microstructure analyses indicate that the surfaces of the CFO films are covered by islands with height from

2.7 to 0.8 nm upon decreasing film thickness from 240 to 6 nm. Magnetic measurement shows that the CFO films exhibit film thickness dependence of anomalous magnetic properties, including two different “magnetic phases” reflected in the magnetization loops, and reduced saturation magnetization and coercivity with decreasing film thickness. Systematic analyses of the microstructure and magnetization loops for the CFO films with different thicknesses imply that the structure defects on the surface and at the interface, together with the antiphase boundaries TPX-0005 molecular weight in the films are responsible for the anomalous magnetic properties of the CFO films. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3608041]“
“Background: Urinary incontinence is one of the most prevalent health problems and a significant cause of disability and dependence

selleck chemicals in the elderly. Pelvic floor exercise is effective in reducing stress urinary incontinence, but few studies have investigated the effect of behavioral management on urge and mixed incontinence.\n\nObjectives: To determine the effects of multidimensional exercise treatment on reducing urine leakage in elderly Japanese women with stress, urge, and mixed urinary incontinence.\n\nDesign: Randomized controlled, follow-up trial.\n\nSettings: Urban community-based study.\n\nParticipants: 127 community-dwelling women aged 70 and older with stress, urge, and mixed urinary incontinence were randomly assigned to the intervention (n = 63) or the control group (n = 64).\n\nMethods: Urine leakage and fitness data were collected at baseline, and after the intervention and follow-up. The intervention group received a multidimensional exercise treatment twice a week for 3-month. After treatment, the participants were followed for 7-month.\n\nResults: There were significant differences in changes of functional fitness and incontinence variables between the intervention and control groups. The intervention group showed urine leakage cure rates of 44.1% after treatment and 39.3% after follow-up (chi(2) = 21.96, p < 0.001): whereas, the control group showed no significant improvement.

A sphere to background ratio of 8:1, with a total Y-90 activity o

A sphere to background ratio of 8:1, with a total Y-90 activity of 3 GBq was used. Measurements were performed for one week (0, 3, 5 and 7 d). he acquisition selleck screening library protocol consisted of 30 min-2 bed positions and 120 min-single bed position. mages were reconstructed with 3D ordered subset expectation maximization (OSEM) and point spread function

(PSF) for iteration numbers of 1-12 with 21 (TOF) and 24 (non-TOF) subsets and CT based attenuation and scatter correction. Convergence of algorithms and activity recovery was assessed based on regions-of-interest (ROI) analysis of the background (100 voxels), spheres (4 voxels) and the central low density insert (25 voxels). For the largest sphere, the recovery coefficient (RC) values for the 30 min-2-bed position, 30 min-single bed and 120 min-single bed were 1.12 +/- 0.20,

1.14 +/- 0.13, 0.97 +/- 0.07 respectively. For the smaller diameter spheres, the PSF algorithm with TOF and single bed acquisition provided a comparatively better activity recovery. Quantification of Y-90 using Biograph mCT PET/CT is possible with a reasonable accuracy, the limitations being the size of the lesion and the activity concentration present. At this stage, based on our study, it seems advantageous to use different protocols depending on the size of the lesion.”
“Background: The French government gave a consensual definition of reinforced care units for Behavioral Buparlisib mouse and Psychological Symptoms in Dementia (BPSD) within the project “Plan Alzheimer 2008/2012.” These Cognitive and Behavioral Units (CBU) differ in resources from the traditional reference units for BPSD management, ABT-737 the Acute Psychogeriatric Units (APU). However, a better understanding of their operational specificities may enhance the CBU and APU synergies.\n\nObjectives: To describe one of the first CBU experiments, with regard to preexisting

BPSD management in an APU in the same geriatric hospital.\n\nParticipants: A total of 129 patients with BPSD, 35 from the CBU and 94 admitted to the APU before opening the colocated CBU.\n\nResults: Patients from the CBU often showed comorbidities and a lower nutritional status, but these conditions were more frequent in the APU (P <= 10(-4)). Severe dementia, night time and aberrant motor behavior, and agitation were more frequent in the CBU (P <= 0.0015). In both the units, about 80% of patients were improved without increased use of psychotropic medications and there was a high discharge rate back home of about 30%.\n\nConclusions: These findings that are still preliminary support a particular role for the CBU for elderly patients showing the most advanced dementia and disruptive BPSD. Colocated APU and CBU may allow for more effective integration of medical and psychiatric care in elderly patients with BPSD with frequent comorbidities.”
“The emphasis on the sequencing of genomes seems to make this task an end in itself.

Despite this,

Despite this, Selleck CT99021 19% of physicians report using amiodarone as first-line prophylaxis of postoperative AF. Data directly comparing the efficacy of these agents in preventing postoperative AF are lacking.\n\nObjective: To determine whether intravenous

metoprolol and amiodarone are equally effective in preventing postoperative AF after cardiac surgery.\n\nDesign: Randomized, prospective, equivalence, open-label, multicenter study. ( registration number: NCT00784316)\n\nSetting: 3 cardiac care referral centers in Finland.\n\nPatients: 316 consecutive patients who were hemodynamically stable and free of mechanical ventilation and AF within 24 hours after cardiac surgery.\n\nIntervention: Patients were randomly assigned to receive 48-hour infusion of metoprolol, 1 to 3 mg/h, according to heart rate, or amiodarone, 15 mg/kg of body weight

daily, with a maximum daily dose of 1000 mg, starting 15 to 21 hours after cardiac surgery.\n\nMeasurements: The primary end point was the occurrence of the first AF episode or completion of the 48-hour infusion.\n\nResults: Atrial fibrillation occurred in 38 of 159 (23.9%) patients in the metoprolol group and 39 of 157 (24.8%) patients in the amiodarone group (P = 0.85). However, the difference (-0.9 percentage point [90% CI, -8.9 to 7.0 percentage points]) does not meet the prespecified equivalence margin of 5 percentage points. The adjusted hazard ratio of the metoprolol group compared with the amiodarone group was 1.09 (95% CI, 0.67 to 1.76).\n\nLimitations: Caregivers were not blinded to treatment allocation, and the trial evaluated only stable patients who were not at particularly elevated risk for AF. The withdrawal of preoperative beta-blocker therapy may have increased the risk for AF in the amiodarone group.\n\nConclusion: The occurrence of AF was similar in the metoprolol and amiodarone groups. However, because of the wide range of the CIs, the authors cannot conclude that the 2 treatments were equally

“Background: TSH receptor click here antibodies (TRAb) are the diagnostic hallmark of Graves’ disease (GD) and immunoassays for their detection have been available for more than 30 years over three generations of laboratory methods. Despite a growing body of data produced by clinical and laboratory research which demonstrates its elevated sensitivity and specificity, TRAb testing is poorly used for diagnosing GD.\n\nThe aim of our systematic review and meta-analysis is to verify the diagnostic performance of TRAb detected with 2nd and 3rd generation immunoassay methods.\n\nMethods: We searched for English articles using MEDLINE with the search terms “TSH receptor antibody assay”, “TSH Receptor antibody tests” and “Graves’ disease”.

(C) 2011 Elsevier B V All rights reserved “
“Recruitment of

(C) 2011 Elsevier B.V. All rights reserved.”
“Recruitment of the growth factor receptor-bound protein 2 (Grb2) by the plasma membrane-associated adapter protein downstream

of kinase 3 (Dok-3) attenuates signals transduced by the B cell antigen receptor (BCR). Here we describe molecular details of Dok-3/Grb2 signal integration and function, showing that the Lyn-dependent activation of the BCR transducer kinase Syk is attenuated by Dok-3/Grb2 in a site-specific manner. This process is associated with the SH3 domain-dependent translocation of Dok-3/ Grb2 complexes into BCR microsignalosomes and augmented phosphorylation of the inhibitory Lyn NSC 23766 target SH2 domain-containing inositol 5′ phosphatase. Hence, our findings imply that Dok-3/ Grb2 modulates the balance between activatory and inhibitory Lyn functions with the aim to adjust BCR signaling efficiency.”
“Recombinant Escherichia coli strains for the production of valuable products are usually generated by transformation with plasmid expression vectors. However, in spite of their usefulness,

common problems associated with plasmid use include segregrational and structural instability as well as undesired copy-number effects. A viable alternative to plasmid use is chromosomal gene integration. Z-IETD-FMK With the purpose of facilitating the process of stable strain generation, a novel chromosomal integration vector was developed and tested. We describe the Alvespimycin construction and use of novel expression vector pLoxGentrc that contains the strong trc promoter (P-trc), a multiple cloning site, the T1 and T2 rrnB terminator sequences, the lacl(q) gene and the aacC1 gene conferring gentamicin resistance

flanked by two loxP sites. As a demonstration of utility, melanin-producing strains of E. coli were generated employing this vector. Melanin is a polymer synthesized by the enzyme tyrosinase using L-tyrosine as substrate. The melA gene encoding a tyrosinase from Rhizobium etli was ligated to pLoxGentrc to generate pLoxGentrcmelA. This plasmid was transformed into E. coli W3110 to generate a melanin-producing strain. A region from this plasmid including P(trc)melA, T1 and T2 rrnB and the aacC1 gene was amplified by PCR employing primers with 45 b regions of homology to the lacZ gene. The PCR product was electroporated into strain W3110 that expressed the lambda-Red enzymes. From this experiment, strain W3110P(trc)melA, was obtained having the melA gene inserted in the lacZ locus. Fermentor cultures with strain W3110/pLoxGentrcmelA grown in the presence and absence of gentamicin as well as W3110P(trc)melA without antibiotic revealed that the latter displays high genetic stability as well as the highest melanin titer. Vector pLoxGentrc should be useful during strain generation processes, enabling direct comparison of plasmid and chromosome-based production systems. (c) 2012 Elsevier Inc. All rights reserved.

The microspheres of various compositions were prepared by an oil-

The microspheres of various compositions were prepared by an oil-in-oil emulsion-solvent

evaporation method. The effect of complexation and presence of cellulose polymers on entrapment efficiency, particle size, and drug release had been investigated. The solid-state characterization was performed by Fourier transform infrared spectroscopy, thermogravimetry, differential scanning calorimetry, and powder X-ray diffractometry. The morphology of MIC was examined by scanning electron microscopy. The in vitro drug release profiles from these microspheres showed the desired biphasic release behavior. After enhancing the solubility of prednisolone by inclusion into HP beta CD, the drug release was easily modified in the microsphere formulation. It was also demonstrated that the CDs in these microspheres were able to modulate several properties such as morphology, drug loading, and AP26113 cell line release properties. The release kinetics of prednisolone from microspheres followed quasi-Fickian and first-order release mechanisms. In addition to this, the f (2)-metric technique was used to check the equivalency of

dissolution profiles of the optimized formulation before and after stability studies, and it was found to be similar. LOXO-101 order A good outcome, matrix microspheres (coded as MIC5) containing PRD-HP beta CD complex, showed sustained release of drug (95.81%) over a period of 24 h.”
“Objective: We previously reported the epidemiology of 2009 Influenza A (H1N1) in our pediatric healthcare facility in New York City during the first wave of illness (May-July 2009). We hypothesized that compared with the first wave, the second wave would be characterized by increased severity of illness and mortality.\n\nDesign: Case series conducted VX-680 Cell Cycle inhibitor from May 2009 to April 2010.\n\nSetting: Pediatric emergency departments and inpatient facilities of New York-Presbyterian

Hospital.\n\nPatients: All hospitalized patients divided by 18 yrs of age with positive laboratory tests for influenza A.\n\nMeasurements and Main Results: We compared severity of illness during the first and second wave assessed by the number of hospitalized children, including those in the pediatric intensive care unit, bacterial superinfections, and mortality rate. Compared to the first wave, fewer children were hospitalized during the second wave (n = 115 vs. 76), but a comparable portion were admitted to the pediatric intensive care unit (30.4% vs. 19.7%; p = .10). Pediatric Risk of Mortality III scores, length of hospitalization in the pediatric intensive care unit, incidence of respiratory failure and pneumonia, and peak oxygenation indices were similar during both waves. Bacterial superinfections were comparable in the first vs. second wave (3.5% vs. 1.3%).

The exponential parameters of the Gaussians are variationally opt

The exponential parameters of the Gaussians are variationally optimized with the aid of the analytical energy gradient determined with respect to those parameters. The calculated state energies are compared with the available experimental data. (C) 2012 American Institute of Physics. []“
“Purpose: To determine the rates of globe-sparing treatment and useful final visual function in patients with primary lacrimal sac/nasolacrimal duct carcinomas treated with multidisciplinary therapy.\n\nMethods: The medical records of 14 patients with primary lacrimal sac/nasolacrimal duct carcinoma treated at 1 institution were retrospectively reviewed.\n\nResults:

The patients were 9 men and 5 women; the median age at diagnosis was 58.5 years (range, 45-73 years). Seven patients presented with epiphora, 7 with a palpable check details mass in the inferomedial orbit, and 2 with dacryocystitis. In 3 patients, the diagnosis of cancer was not considered

until during or after dacryocystorhinostomy. Seven patients had squamous cell carcinoma, 2 transitional cell carcinoma, 2 adenoid cystic carcinoma, and 1 each adenocarcinoma, poorly differentiated carcinoma, and inverted papilloma with carcinoma in situ transformation. Nine Napabucasin mouse patients underwent surgical resection of the lacrimal sac and nasolacrimal duct and resection of the medial upper and lower eyelids, including canaliculi, partial ethmoidectomy, and medial maxillectomy. One patient underwent lacrimal sac biopsy only as another primary malignancy was TPX-0005 discovered during the work-up for systemic disease. Four patients underwent orbital exenteration because of extensive involvement of the orbital soft tissue. Radiotherapy was recommended for 13 patients; in 1 patient, radiotherapy was not recommended because the patient had an inverted papilloma with carcinoma in situ transformation that was completely excised. The median radiation dose was 60 Gy. Eight patients received chemotherapy either concurrent with radiation therapy (5 patients), as neoadjuvant treatment (1 patient), or for progressive or metastatic disease (3 patients). The median follow-up time was 27 months (range, 6-96 months). In

10 patients, the globe was spared. In 9 of these 10 patients, visual acuity was the same as at baseline or better than 20/40 at last follow up.\n\nConclusions: With multidisciplinary therapy, the eye can be spared and reasonable visual function can be preserved in most patients with primary lacrimal sac/nasolacrimal duct carcinomas.”
“Objective: To investigate experimentally the time dependent changes of latency, amplitude, threshold of neural response in injured rat facial nerve in a nerve-crush trauma model.\n\nMaterials and Methods: Thirty Wistar rats weighing 220-280 g (12-16 week), were grouped for permanent and transient nerve injury during time course analysis of electrophysiological changes at 1st week, and 1st, 3rd and 6th months.

We evaluated the association between socioeconomic status and the

We evaluated the association between socioeconomic status and the incidence of sudden cardiac arrest, a condition that accounts for a substantial proportion of cardiovascular-related deaths, in seven large North American urban populations.\n\nMethods: Using a population-based registry, we collected data on out-of-hospital sudden cardiac arrests occurring at home or at a residential institution from Apr. 1, 2006, to Mar. 31, 2007. We limited the analysis to cardiac arrests in seven metropolitan areas in the United States (Dallas, Texas; Pittsburgh, Pennsylvania;

Portland, Oregon; and Seattle-King County, Washington) and Canada (Ottawa and Toronto, Ontario; and Vancouver, British Columbia). Each incident was linked to a census tract; tracts were classified into quartiles of median household income.\n\nResults: A total of 9235 sudden cardiac arrests were included in the analysis. For all sites combined, the incidence of sudden cardiac arrest in the lowest socioeconomic quartile was nearly double that in the highest quartile (incidence rate ratio [IRR] 1.9, 95% confidence interval [CI] 1.8-2.0). This disparity was greater among people less than 65 years old (IRR 2.7, 95% CI 2.5-3.0) than among those 65 or older (IRR 1.3, 95% CI 1.2-1.4). After adjustment for study site and for population age structure of each census

tract, the disparity across socio economic quartiles for all ages combined was greater in the United States (IRR 2.0, 95% CI 1.9-2.2)

than in Canada (IRR Galardin clinical trial 1.8, 95% CI 1.6-2.0) (p < 0.001 for interaction).\n\nInterpretation: The incidence of sudden cardiac arrest at home or at a residential institution was higher in poorer neighbourhoods of the US and Canadian sites studied, learn more although the association was attenuated in Canada. The disparity across socioeconomic quartiles was greatest among people younger than 65. The association be tween socio economic status and incidence of sudden cardiac arrest merits consideration in the development of strategies to improve survival from sudden cardiac arrest, and possibly to identify opportunities for prevention.”
“Background: Therapeutic hypothermia (TH, 30 degrees C) protects the brain from hypoxic injury. However, TH may potentiate the occurrence of lethal ventricular fibrillation (VF), although the mechanism remains unclear. The present study explored the hypothesis that TH enhances wavebreaks during VF and Si pacing, facilitates pacing-induced spatially discordant alternans (SDA), and increases the vulnerability of pacing-induced VF\n\nMethods and Results: Using an optical mapping system, epicardial activations of VF were studied in 7 Langendorff-perfused isolated rabbit hearts at baseline (37 degrees C), TH (30 degrees C), and rewarming (37 degrees C). Action potential duration (APD)/conduction velocity (CV) restitution and APD alternans (n=6 hearts) were determined by S1 pacing at these 3 stages.

The activity and expression levels of SIRT1 and expression of its

The activity and expression levels of SIRT1 and expression of its downstream lipid-metabolism genes were measured.\n\nResultsIn replicon cells, the level of ROS and MDA increased, SOD activity and the value of NAD(+)/NADH decreased, then the activity and expression level of mRNA and protein of SIRT1 reduced. Inhibition of SIRT1 decreased phosphorylation of forkhead box O1 (FoxO1), which not only upregulated SREBP-1c, FAS, ACC, SREBP-2, HMGR and HMGS genes and increased

fatty acid synthesis; see more but also downregulated PPAR- and CPT1A genes and decreased fatty acid -oxidation. Interferon treatment restored aforementioned changes. SIRT1 activator improved lipid metabolism disorders by an increase in fatty acid -oxidation and a decrease in TG and TC synthesis and inhibited HCV replication.\n\nConclusionHCV

replication decreasing NAD(+)/NADH ratio may downregulate the activity and the expression of SIRT1, then change the expression profile of lipid metabolism-related genes, thereby cause lipid metabolism disorders of hepatocytes and promote HCV replication. Treatment with SIRT1 activator ameliorates lipid metabolic AG-120 supplier disorders and inhibits HCV replication.”
“The authors report the case of a patient arrived in psychiatric ambulatory with a panic-like symtomatology. The patient refers that the symptomatology appeared after taking sibutramine. She took it with the intent to lose weight. After the disturbance beginning, the patient interrupted the sibutramine treatment but the psychiatric symptomatology didn’t regress completely. It is supposed, in the light of this new evidence and in conformity of DSM-IV criteria, the diagnosis of substance-induced

anxiety disorder with panic attack. Paroxetine and alprazolam were administered to the patient, with the resolution of the anxious symptoms. After eight months the treatment was suspended, since the patient referred to be pregnant; in any case, during the pregnancy no other panic attacks occurred. After six months from the suspension of the drugs, the patient can no longer be classified as affected by panic attack according to the DSM-IV criteria.”
“Purpose. – Acquired haemophilia A (AHA) is a rare bleeding disorder, due to the presence of an inhibitor directed against factor VIII (FVIII). About 50% of the AHA are idiopathic, while the remaining 50% are related to an underlying disorder or condition (autoimmune diseases, malignancies, postpartum, etc.).\n\nPatients and methods. – We report on a monocentric retrospective cohort of 39 patients with AHA. Data were collected and compared to recent published data.\n\nResults. – Thirty-nine patients were admitted for AHA between 1993 et 2011. Mean age at diagnosis was 71.3 years, and we noted a marked male predominance. Although the majority of patients presented a bleeding event at diagnosis (94.9%), the hemorrhagic mortality was low (2.6%).