The functional association of this SNP with liver fibrosis and its biological role in other liver diseases
requires further investigation and validation. Distribution of CC (2.4%), CT (19.0%), and TT (78.6%) genotypes and relationship with PCA Disclosures: Nezam H. Afdhal – Consulting: Merck, Vertex, Idenix, GlaxoSmithKline, Springbank, Gilead, Pharmasett, Abbott; Grant/Research Support: Merck, Vertex, Idenix, GlaxoSmithKline, Springbank, Gilead, Pharmasett, Abbott Thomas J. Urban – Patent Held/Filed: Schering Plough Zachary D. Goodman – Consulting: SCH 900776 cell line Gilead Sciences, Abbvie; Grant/Research Support: Gilead Sciences, Fibrogen, Galectin Therapeutics, Merck, Vertex, Synageva, Conatus Keyur Patel – Advisory Committees or Review Panels: Merck; Consulting: Gilead Sciences, Santaris, Akros, Nitto Denko; Grant/Research Support: Bristol Myers Squibb Dongliang Ge – Employment: Gilead Sciences, Inc Zhaoshi Jiang – Employment: Gilead Sciences, Inc.; Stock Shareholder: Gilead Scieces, Inc. Xi Zhao – Employment: Gilead Sciences Matthew Paulson – Employment: Gilead Sciences Anuj Gaggar – Employment: Gilead FK506 molecular weight Sciences Jeffrey Bornstein – Employment: Gilead Sciences Mani Subramanian – Employment: Gilead Sciences John G. McHutchison – Employment: Gilead Sciences; Stock Shareholder: Gilead Sciences David B. Goldstein – Advisory Committees
or Review Panels: Astra Zeneca, NIH, Biogen, Gordon Research Conference; Board Membership: Knome; Consulting: glaxo smithkline, Severe Adverse Events Consortium, Roche, Gilead Sciences, Inc, Scienta Advisors; Employment: Duke University; Grant/Research Support: UCB, NIH, Biogen, Henry M Jackson Foundation, SAIC, Inc, Bill & Melinda Gates Foundation, Eisai, Inc; Patent Held/Filed: patent IL28B findings, patent ITPA findings, Merck & Company; Speaking and Teaching: Current Biology magazine, Illumina, Regeneron, Dermatology Society; Stock Shareholder: Pfizer Rohit Loomba – Consulting: Gilead Inc, Corgenix Inc, Janssen and Janssen Inc;
Grant/Research Support: Daiichi Sankyo Inc, AGA, Merck Inc Alexander J. Thompson – Advisory Committees or Review Panels: Merck, Inc, Roche, Janssen (Johnson & Johnson), BMS, GSK Australia, 4-Aminobutyrate aminotransferase Novartis, GILEAD Sciences, Inc; Consulting: GILEAD Sciences, Inc; Grant/Research Support: Merck, Inc, Roche, GILEAD Sciences, Inc; Speaking and Teaching: Merck, Inc, Roche, BMS, Janssen (Johnson & Johnson) The following people have nothing to disclose: Xin Guo, Sarah E. Kleinstein, Nanye Long Purpose: Shear waves have been recognized to be useful in assessing liver fibrosis in a non-invasive manner. Reports have shown its diagnostic performance in evaluating the degree of severity in liver cirrhosis. We aimed to identify factors, such as fibrosis, that associate with liver stiffness, and also to evaluate the cancer risk.