A prospective analysis capturing all costs and patient quality of life is required for further assessment. (J Burn Care Res 2012;33:e275-e279)”
“Background: Little data exists on temporal changes in the care of children with common surgical conditions. We hypothesized that an increasing proportion of procedures are performed at pediatric hospitals over time, and that PND-1186 concentration outcomes are superior at these centers. Methods: We conducted a retrospective cohort study using Washington State discharge records for children 0-17 years old undergoing appendectomy (n = 39,472) or pyloromyotomy (n = 3,500). Pediatric hospitals
were defined as centers with full-time pediatric surgeons. Outcomes were examined for two time periods (1987-2000, 2001-2009). Results: From 1987 to 2009, the proportion of procedures performed at pediatric hospitals steadily increased. The percentage for appendectomies increased from 17% to 32%, and that for pyloromyotomies increased from 57% to 99%. For pyloromyotomy, care
at a pediatric hospital was associated with decreased risk of postoperative complications (OR = 0.36, p smaller than 0.001) for both time periods. Appendectomy outcomes did not differ significantly in the early time period, but in the later time period specialist care was associated with lower risk of complications in children Blebbistatin in vitro smaller than 5 years (OR = 0.54, p = 0.03). Conclusion: There has been a shift towards pediatric hospitals for certain procedures, with a widening disparity in outcomes for younger children. These results suggest that procedures in younger patients may best be performed by providers familiar with these patient populations. (C) 2014 Elsevier
Inc. All rights reserved.”
“Selectivity is one of the most important criteria for the design of new catalytic processes. More selective catalysis could be both cheaper and greener because it does not waste reactants, does not require expensive separation procedures, and generates fewer toxic byproducts. Traditionally, control of selectivity in heterogeneous catalysis has been hampered by both a lack of understanding of the molecular details that define AR-13324 such selectivity and the limited range of synthetic tools available to make low catalysts with the specific properties required. However, progress in surface science as well as in nanotechnology and self-assembly are providing greater molecular understanding and a wider synthetic range to address these limitations.\n\nIn this Account, we describe our studies using model systems to pinpoint the mechanistic factors that define selectivity in a number of increasingly subtle hydrocarbon dehydrogenation and hydrogenation reactions. The first examples show how the electronic properties of a metal surface affect the regioselectivity of hydrogen elimination from alkyl species adsorbed on that surface.