The 1RT and 2RT groups participated in a progressive high intensity protocol using a weights machine and free weights for resistance with a training regimen of 2 sets of 6 to 8 repetitions for arm and leg exercises. The BAT group’s

Galunisertib ic50 program consisted of exercises for stretching, range of motion, pelvic floor and balance, and relaxation techniques. Outcome measures: The primary outcome was change in the executive cognitive function of selective attention and conflict resolution as measured by the Stroop test at 6 and 12 months. The Stroop test assesses the time taken to name words of colours typed in incongruent ink colours. Secondary outcome measures were cognitive functions of set shifting and working memory, whole-brain volume, and functional measures of gait speed and muscular performance. Results: 135 participants (87%) completed the study and were included in the analysis. At 6 months there was no between-group difference but at 12 months, task performance in the Stroop test had improved by –2.9 s in the 2RT group compared to BAT (95% CI –12.2 to –0.8) and –4.3 s in the 1RT compared to BAT (95% CI –13.8 to –2.5) representing improvement of 11% and 13% in 2RT and 1RT groups, respectively, and deterioration of 0.5% in the BAT group. Peak quadriceps muscle power increased by 13% in the 2RT group, but decreased by 8% in 1RT

and 16% in the BAT group. There was a small but significant reduction in whole brain volume in 1RT and 2RT compared with BAT. The groups did not differ significantly on the remaining secondary outcomes. Conclusion: Twelve months of once or twice-weekly resistance training can improve first BMS-354825 supplier the cognitive functioning of older women living in the community. This randomised controlled trial (RCT) contributes to the growing body of literature showing that physical activity can improve cognitive function in cognitively healthy

older adults (Angevaren et al 2008). Liu-Ambrose and colleagues demonstrated that only one 60-minute session of supervised progressive resistance training per week for 12 months improved participants’ selective attention and conflict resolution in comparison to a twice weekly balance and tone training control group. This improvement was greater in the once weekly resistance training group than in the twice weekly group. However, the authors did not offer any explanations for this dose effect. The authors conclude that the positive cognitive effect may be selective for executive functions since other secondary cognitive outcomes did not improve, however the battery of cognitive tests used was small. Furthermore the authors reported that the improvement in executive functions was significantly associated with increased gait speed. This important finding adds further weight to the relevance of gait speed for cognitive function and survival (Soumaré et al 2009, Hardy et al 2007).