Ovarian cancers comprise a broad spectrum of malignancies, ranging from serous to mucinous, endometrioid, clear cell and other histologic subtypes. These histotypes have been recently

associated with distinct molecular profiles and polymorphisms, supporting the idea that the distinct molecular pathways and genotype may strongly affect germinal histotypes in ovarian cancer [27–30]. As demonstrated in our research, the frequencies of A allele and combined GA + AA genotypes in p73 rs6695978 G > A were statistically elevated in mucinous ovarian cancer this website compared with other subtypes. In all histologic types, the prognosis of mucinous ovarian cancer is unsatisfactory and prone to metastasis and drug resistance [31], which introduces difficulties and challenges into clinical treatment. The median survival (MS) of mucinous adenocarcinomas did not differ significantly between the groups interpreted as primary or metastatic, but the overall survival (OS) of mucinous adenocarcinomas is significantly less than that for women with serous carcinoma [32]. Mucinous carcinomas are independent predictors of poor prognosis

in stage III/IV ovarian cancer [33]. Consequently, our study indicates that the rs6695978 A allele may be more closely related to the occurrence www.selleckchem.com/products/jph203.html of mucinous ovarian cancer and individuals carrying the AA and GA genotypes may suffer from poorer prognoses. With Cytidine deaminase respect to the clinical stage, Volasertib cost differentiation degree and lymph node status in ovarian cancer, which can guide clinical treatment and outcomes, there is also mounting evidence that p73 protein expression may play a vital role in malignant transformation, clinical stage, differentiation degree and metastasis of ovarian cancer [34]. The lower the differentiation degree, the higher the level of p73 expression. Increasing

the expression of the p73 protein in tumor cells may strengthen the suppression of cellular apoptosis; the survivability and malignancy of the tumor are enhanced accordingly. Thus, tumor cells may have an easier time to invade the surrounding tissues and metastasize to the lymph nodes, which shorten the survival of ovarian cancer patients. In this study, we clarified the association of the A allele frequency in the p73 rs6695978 G > A with a low degree of differentiation and lymph node metastasis, which is similar to what was seen in previous studies on the status of p73 expression in ovarian cancer. However, the biological relevance for an association between rs6695978 A allele and ovarian cancer remains unclear. Therefore, we will sought to assess whether there was a necessary link between p73 expression status and the p73 rs6695978 G > A polymorphism in the next step. Further investigation in a larger sample size involved molecular mechanisms are indispensable.