Ongoing collaborative research is aiming to improve assessment of individual SUDEP risk and to develop preventive measures based on pathophysiological considerations. This review focuses on novel findings in humans and animal models related to pathophysiology, risk factors and prevention of SUDEP.\n\nRecent findings\n\nPotential mechanisms CAL-101 PI3K/Akt/mTOR inhibitor include cardiac arrhythmia, postictal cardiomyopathy, depressed autonomic

function and seizure-related respiratory failure. Electrocardiography predictors of sudden cardiac death have been described in people with chronic epilepsy, but their significance for SUDEP remains to be confirmed. Epidemiological risk factors comprise male sex, young age at epilepsy onset, symptomatic cause, longer duration of epilepsy, frequent convulsive seizures and polytherapy. Efficacious adjunctive antiepileptic medication may reduce the risk of SUDEP.\n\nSummary\n\nNovel clinical features may help to define better the individual

risk of SUDEP. Potentially therapeutic strategies including pharmacological modulation of respiratory arrest and implantation of cardiac devices could reduce the risk of SUDEP in some individuals. Antiepileptic drugs lower the risk, stressing the importance of successful seizure control JIB-04 supplier for prevention.”
“The present study aimed to investigate the effect of piperine, a major component of black pepper, on the oral exposure of fexofenadine in rats. Pharmacokinetic parameters of fexofenadine were determined in rats following an oral (10 mg/kg) or intravenous (5 mg/kg) administration of fexofenadine in the presence and absence of piperine (10 or 20 mg/kg, given orally). Compared to the control group given fexofenadine alone, the combined use of piperine increased the oral exposure (AUC) of fexofenadine by 180% to 190% while there was no significant change in C(max) and T(1/2) of fexofenadine in rats. The bioavailability of fexofenadine was increased by approximately 2-folds via the concomitant use of piperine. Furthermore, T(max) tends to be increased which might be

attributed to the delayed gastric emptying in the presence of piperine. In contrast, CRT0066101 research buy piperine did not alter the intravenous pharmacokinetics of fexofenadine, implying that piperine may increase mainly the gastrointestinal absorption of fexofenadine rather than reducing hepatic extraction. In conclusion, piperine significantly enhanced the oral exposure of fexofenadine in rats likely by the inhibition of P-glycoprotein-mediated cellular efflux during the intestinal absorption, suggesting that the combined use of piperine or piperine-containing diet with fexofenadine may require close monitoring for potential drug-diet interactions.”
“The main physicochemical properties of non-starch polysaccharides (NSP) that are of nutritional significance include hydration properties, viscosity, cation exchange capacity and absorptive properties of organic compounds.