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21. O’Farrell HC, Pulicherla N, Desai PM, Rife JP: Recognition selleck chemicals of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution. RNA 2006,12(5):725–733.PubMedCrossRef Competing interests The authors declare that they have no competing interests. Authors’ contributions HCO carried out all experiments and drafted the manuscript. JPR conceived of the study, participated in its design and coordination, participated in construction of the knockout strain, and helped to draft the manuscript. All authors read and approved the final manuscript.”
“Background Streptococcus pneumoniae infections remain a major cause of morbidity and selleck screening library mortality worldwide, causing diseases which range in severity from otitis media and sinusitis, to pneumonia, septicaemia and meningitis [1]. S. pneumoniae is a commensal of the human nasopharynx [2]. The diversity of pneumococci was first evidenced by serotyping of their capsular polysaccharides resolving into more than 93 serotypes [3, 4]. However, only 16 serotypes cause approximately 90% of invasive disease worldwide [1, 5].