Mol Microbiol 2005, 55:1883–1895.PubMedCrossRef 65. Christner M, Franke G, Schommer N, Wendt U, Wegert K, Pehle P, Kroll G, Schulze C, Buck F, Mack
D, Aepfelbacher M, Rohde H: The giant extracellular matrix binding protein of Staphylococcus epidermidis mediates biofilm accumulation and attachment to fibronectin. Mol Microbiol 2010, 75:187–207.PubMedCrossRef 66. Arciola CR, Baldassarri L, Montanaro : Presence of icaA and icaD Genes and Slime Production in a Collection of Staphylococcal Strains from Catheter-Associated Infections. J Clin Microbiol 2001, 39:2151–2156.PubMedCrossRef 67. De Silva GDI, Kantzanou M, Justice A, Massey RC, Wilkinson AR, Day NPJ, Peacock SJ: The ica operon and biofilm production in coagulase-negative staphylococci associated with carriage and disease in a neonatal intensive care unit. J Clin www.selleckchem.com/products/azd2014.html Microbiol
2002, 40:382–388.PubMedCrossRef 68. Foretinib concentration Ziebuhr W, Krimmer V, Rachid S, Lobner I, Gotz F, Hacker J: A novel mechanism of phase variation of virulence in Staphylococcus epidermidis: evidence for control of the polysaccharide intercellular adhesin synthesis by alternating insertion and excision of the insertion sequence element IS256. Mol Microbiol 1999, 32:345–350.PubMedCrossRef 69. Nilsdotter-Augustinsson A, Koskela A, Öhman L, Söderquist B: Characterization of coagulase-negative Selleck PF-6463922 staphylococci isolated from patients with infected hip prostheses: use of phenotypic and genotypic analyses, including tests for the presence of the ica operon. Eur J Clin Microbiol Infect Dis 2007, 26:255–265.PubMedCrossRef 70. Mack D, Bartscht K, Fischer C, Rohde H, De Grahl C, Dobinsky
S, Horstkotte MA, Kiel K, Knobloch JK-M: Genetic and Biochemical Analysis of Staphylococcus epidermidis Biofilm Accumulation. Meth Enzymol 2001, 336:215–239.PubMedCrossRef Authors’ contributions AS carried out experimental work and drafted the manuscript. FK designed and participated in experiments involving analysis of clinical strains. MK participated in experiments for 20-kDaPS isolation and helped to draft the manuscript. LH participated in experiments involving comparison of PIA and 20-kDaPS by immunofluorescence Metformin solubility dmso and contributed to design of these experiments. TW participated in experiments involving comparison of PIA and 20-kDaPS by ELISA and contributed to design of these experiments. AD participated in the design of the study. GD contributed to design of phagocytosis experiments. NK contributed to design of phagocytosis experiments, structural elucidation, data interpretation and revised the manuscript. DM designed the study and experimental work involving comparison of PIA and 20-kDaPS, interpreted acquired data and revised the manuscript.