MC concentrations detected in oysters harvested in the vicinity of the southern drainage gate on December 10, 2007, were 0.37 μg/g wet weight (2.0 μg/g dry weight, Table 4). As the wet weight of this specimen was 12.0 g, the MC content of this single oyster was 4.4 μg, well above the TDI for a 60 kg adult (2.4 μg). The potential health implications of these MC levels are further exacerbated by local customs, which recommend

regular consumption of oysters by lactating mothers due to their high mineral content. Highly concentrated MCs were also detected in the liver, ovaries, and muscle of mullets collected from the reservoir (Table Gefitinib purchase 5). Based on the levels described here, it is strongly recommended that people avoid eating mullets caught in the reservoir. Mullets found in the reservoir appear to be limited to large individuals ∼80 cm in length, suggesting that these fish Cabozantinib clinical trial may have been trapped within

the reservoir since at least May 2002, the end of a short-term investigation in which the gates were left open. MCs are cyclic nonribosomal peptides. They can be very toxic for both plants and animals at sufficient doses. For acute toxicity, the LD50 of MC-LR is 43 μg/kg (mouse, i.p., Gupta et al., 2003). At lower doses, MCs inhibit protein phosphatase 1 and 2A, and promote the development of liver cancer (reviewed by Campos and Vasconcelos (2010)). However, liver dysfunction is a disease in which symptoms are slow to appear, and one that can be caused by a number of factors, making the true contribution of MCs difficult to ascertain. While the majority of the water found in Pyruvate dehydrogenase lipoamide kinase isozyme 1 the main reservoir is not used for agriculture, water from the mouth of the river is used. MC levels at this location were 0.60 μg/L on September 16, 2009, in water drawn up for the irrigation of reclaimed farmland. As the irrigation water had

already been filtered to some degree by the time it was tested, this suggests that the majority of MCs exist as dissolved particles. The molecular size of MCs are ∼1000 M, suggesting that they may be taken up into plants via the root hairs, or through the epidermis of vegetables ( Järvenpää et al., 2007 and Crush et al., 2008). In the UK, a case of MC levels reaching 2.5 μg/g dry weight was detected in lettuce leaves that had been irrigated with water containing cyanobacteria, including M. aeruginosa. Furthermore, not only were MCs detected in lettuce cells, viable M. aeruginosa cells remained in the leaves for up to 10 days after the harvest ( Codd et al., 1999). Within the reservoir, efforts have been made to reduce the levels of cyanobacteria in the water, including filtering and ozone treatment, however these efforts have ultimately proved ineffective. To filter the ∼400 million tons of water discharged from the reservoir every year, it would be necessary to process the water at a rate of 45,000 tons per hour, a level far beyond what is practical.