Design: We conducted a prospective cohort study [the European Pro

Design: We conducted a prospective cohort study [the European Prospective Investigation into Cancer buy Dinaciclib and Nutrition Physical

Activity, Nutrition, Alcohol Consumption, Cessation of Smoking, Eating Out of Home, and Obesity (EPIC-PANACEA) project] in 373,803 individuals (103,455 men and 270,348 women; age range: 25-70 y) from 10 European countries. Anthropometric measurements were obtained at recruitment and after a median follow-up time of 5 y. The relative Mediterranean Diet Score (rMED; score range: 0-18) was used to assess adherence to the MDP according to the consumption of 9 dietary components that are characteristic of the Mediterranean diet. The association between the rMED and 5-y weight change was modeled through multiadjusted mixed-effects linear regression.

Results: Individuals with a high adherence to the MDP according to the rMED (11-18 points) showed a 5-y weight change of 0.16 kg (95% CI: 0.24, 0.07 kg) and were 10% (95% CI: 4%, 18%) less likely to develop overweight

or obesity than were individuals with a low adherence to the MDP (0-6 points). The low meat content of the Mediterranean diet seemed to account for most of its positive effect against weight gain.

Conclusion: This study shows that promoting the MDP as a model of healthy eating may help to prevent weight gain and the development of obesity. Am J Clin Nutr 2010;92:912-21.”
“The objective of this study was to PI3K inhibitor compare puborectal muscle integrity and bulk in women with both major levator ani (LA) defects on MRI and pelvic

organ prolapse (POP) to women with normal LA muscle and normal support.

This is a case-control study comparing 24 cases with known major LA defects and POP to 24 controls with normal LA and normal support. Axial T-2 weighted MRI scans of the pelvis were evaluated for integrity of the puborectal muscle and degree of muscle bulk.

There were no significant group differences in age, body mass index, vaginal deliveries, or hysterectomy status. In all 48 subjects, the puborectal muscle was visible and had no disruption noted. There was no difference in muscle bulk between groups (control/case, thin 42% vs. 25%, average 42% vs. 38%, thick-17% vs. 38%; P = 0.47).

Defects and loss of muscle bulk in the puborectal muscle are not seen on MRI in women with major LA defects and POP.”
“We present first-principles electronic structural calculations of the quasiparticle and optical spectra of two silicon phases, Si-XII and the recently predicted phase of Si in the body-centered-tetragonal structure. The quasiparticle spectra calculated within the GW approximation predict that both of these materials are indirect bandgap semiconductors with small bandgaps. The optical spectra of these materials are obtained by solving the Bethe-Salpeter equation taking into account electron-hole interactions. Comparison is made to other phases of silicon commonly used in photovoltaic applications.

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