Daily injection of 25 mu g/100 gm body weight L-thyroxine (T4, Sigma-Aldrich) for 14 days was performed in 14 rats to induce hyperthyroidism. Seven L-thyroxine injected rats were in the hyperthyroid group. The remaining 7 rats (recovery group) underwent operation after a 28-day washout period to determine spontaneous recovery from hyperthyroidism. At each operation seminal vesicle catheterization
was done to measure intraluminal pressure and bulbospongiosus muscle dissection was performed for electromyography. After intraperitoneal administration of 5 mg/kg para-chloroamphetamine physiological parameters related to the ejaculatory process were measured.
Results: The interval between para-chloroamphetamine administration and first ejaculation was significantly decreased in the hyperthyroid rat group compared with that in the control group (mean SD +/- 202.8 +/- 22.3 vs 465.4 +/- 104.6 seconds, p = 0.001). Seminal vesicle Selleck LGK974 phasic contraction frequency was significantly higher than control group values in hyperthyroid rats (for 30 minutes 32.3 +/- 13.9, p = 0.047). The mean AUC of bulbospongiosus muscle electromyography activity was also significantly increased in this group (11.1 +/- 4.1 V per second x 10(-4), p = 0.0001). All parameters in recovery and control group rats were not significantly differed from each other.
Conclusions: Hyperthyroidism leads
to enhanced seminal vesicle buy Elacridar contraction frequency and bulbospongiosus muscle contractile activity in rats. Hyperthyroidism affects the emission and expulsion phases of ejaculation in reversible fashion.”
“Objective: To explore the presence, clinical characteristics, anatomical foci in image and mechanism of hemispatial neglect (HSN), neglect
test battery and single-photon emission computed tomography Selinexor cost (SPECT) regional cerebral blood flow (rCBF) imaging were performed on patients with stroke.
Methods: Thirty dextromanual patients who were diagnosed as having unilateral stroke clinically were recruited. A neglect test battery including line bisection test, star cancellation test and drawing test was performed on the subjects. The severity of neglect was measured on neglect tests. The lowest rCBF, the range with decreased rCBF, number of the foci with decreased rCBF, the flow deficit size and the total number of pixels in the foci were measured on SPECT rCBF imaging.
Results: Twenty-five patients were diagnosed as having HSN by the neglect test battery. Contralateral neglect (CN) and ipsilateral neglect (IN) were observed in both right and left hemisphere strokes. Oil SPECT imaging, the patients with neglect had decreased rCBF in the frontal cortex most often; followed by the parietal, occipital and temporal cortices; and basal ganglia and thalamus in some cases. The patients who had two or more regions damaged showed neglect more often and severity.