(C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 120: 3357-3362, 2011″
“Aims: To establish a causal relationship between the gene expression GSK1838705A profiles of angiogenetic molecular markers, including epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 (HIF-1). in rectal cancer and the local responsiveness
to neoadjuvant chemoradiotherapy and subsequent disease recurrence.
Materials and methods: We examined the pre-treatment tumour biopsies (n = 40) obtained from patients with rectal adenocarcinoma (clinical International Union Against Cancer stage II/III) who were scheduled to receive neoadjuvant 5-fluorouracil-based chemoradiotherapy for EGFR, VEGF and HIF-1 expression by quantitative real-time polymerase chain reaction.
Results: Responders (patients with significant tumour regression, i.e. pathological grades 2/3) showed significantly lower VEGF, HIF-1 and EGFR gene expression levels than the non-responders (patients with insignificant tumour regression, i.e. pathological grades 0/1) in the pre-treatment tumour biopsies. The elevated expression level of each gene could predict patients with a low response to chemoradiation. During the median follow-up of all patients (41 months; 95% confidence
interval 28-60 months), 6/40 (15%) developed disease recurrence. Although local responsiveness to neoadjuvant chemoradiotherapy was associated with neither local nor systemic disease recurrence, lymph node metastasis and an elevated VEGF gene expression level were independent SB202190 clinical trial predictors of systemic disease
recurrence. The 3-year disease-free survival rates of the patients with lower VEGF or EGFR expression levels see more were significantly lower than those of patients with higher VEGF or EGFR expression levels.
Conclusions: Analysing VEGF expression levels in rectal cancer may be of benefit in estimating the effects of neoadjuvant chemoradiotherapy and in predicting systemic recurrence after rectal cancer surgery. (C) 2010 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.”
“Immediate implant restoration of single implants may demonstrate a positive effect on pen-implant soft tissue. Placement of a provisional restoration following implant surgery can create soft tissue contours that resemble normal gingival topography before placement of the definitive prosthesis. This article describes a staged approach of the mandibular permanent right central incisor, which was congenital missing. The proper space for restoration of the missing incisor was created through orthodontic treatment. The scheduled implant site was reconstructed using autogenous bone harvested from the chin region. After a healing period of four months, an implant was installed with the connection of a fixed provisional crown to a prefabricated temporary abutment.