As disease progresses, the weakness becomes more widespread, mobility and function of upper limbs undergo a decline and patients may become quadriplegic.

Patients gradually lose the ability to articulate words and phrases up to the total loss of verbal communication, that is, anarthria. Moreover, since also limbs mobility is impaired, it deprives patients of the ability to use gestural communication. Since patients may completely lose the ability to communicate, they could gain enormous benefit from technical support and augmentative compound screening assay communication strategies to continue communication, despite the physical impairment that otherwise would prevent it. Thus, several questions arise: Inhibitors,research,lifescience,medical is communication possible despite Inhibitors,research,lifescience,medical motor and cognitive impairments in ALS patients? Moreover, is technology at hand to ensure patients

a good quality of communication? In this work, we attempt to answer these questions with a literature-based approach, trying furthermore to make some consideration about future challenges. Technology represents nowadays a common approach to give and/or improve communication in ALS patients. In particular, augmentative and alternative communication (AAC) can be considered as a form of compensation, Inhibitors,research,lifescience,medical which aims to help and improve communication abilities of individuals with difficulties in using common channels of communication, especially verbal and written. The AAC systems are defined augmentative because they extend or may even replace means of communication

for Inhibitors,research,lifescience,medical physically impaired people. At the same time, they are defined alternative as they use multimodal methods of communication, which are different from the traditional ones. AAC aims to compensate for a temporary or permanent disability of communication (both verbal and written or gestural) and it gives patients the opportunity to maintain their communicative function by producing written or spoken messages, adopting methodologies that range from simple technology Inhibitors,research,lifescience,medical (as alphabetic tables) to high-tech computer systems, such as eye-tracking (ET) and brain-computer interface PAK6 (BCI) devices. The development of these advanced AAC systems allow to bypass the motor difficulties present in ALS patients. In particular, BCIs could be used also in moderate to severe stages of the disease, since they do not require preserved ocular-motor ability, which is necessary for ET applications. BCI uses neurophysiological signals as input commands to control external devices, bypassing motor output, and conveying messages directly from the brain to a computer. Despite the advantages provided by BCI systems, to date they show some limitations, which concern technical and psychological issues that prevent to obtain optimal performances with every subject. Unfortunately, communication is just one of the problems in ALS patients.