6 15.9-47.8 <0.0001 Septic shock 14.6 8.7-24.4 <0.0001

Healthcare associated Selleckchem Ruboxistaurin infection 3.1 2.2-4.5 <0.0001 Source of infection       Colonic non-diverticular perforation 21 9.9-44.6 <0.0001 Small bowel perforation 125.7 29.1-542 <0.0001 Complicated diverticulitis 11 4.9-25.2 <0.0001 Post-operative infections 19.1 9.3-39.3 <0.0001 Delayed initial intervention 2.6 1.8-3.5 <0.0001 Immediate post-operative clinical course       Severe sepsis 33.8 19.5-58.4 MRT67307 <0.0001 Septic shock 59.2 34.4-102.1 <0.0001 ICU admission 18.6 12-28.7 <0.0001 Comorbidities       Malignancy 3.6 2.5-15.1 p < 0.0001 Immunosoppression 1.0 3.2-7.5 p < 0.0001 Serious cardiovascular disease 4.5 3.2-6.3 p < 0.0001 The setting of acquisition was also a variable found to be predictive of patient mortality (healthcare-associated infections: OR = 3.1; 95%CI = 2.2-4.5; p < 0.0001). Among the various

sources of infection, colonic non-diverticular perforation (OR = 21; 95%CI = 9.9-44.6 p < 0.0001), complicated diverticulitis (OR = 11; 95%CI = 4.9-25.2; p < 0.0001), small bowel perforation (OR = 14.3; 95%CI = 6.7-30.3; p < 0.0001) and post-operative infections (OR = 19.1; 95%CI = 9.3-39.3; p < 0.0001) were significantly correlated with patient mortality. Mortality rates did not vary to a statistically significant degree between patients MM-102 manufacturer who received adequate source control and those who did not. However, a delayed initial intervention (a delay exceeding 24 hours) was associated with an increased mortality rate (OR = 3.6; 95%CI = 1.9-3.7;

p < 0.0001). The nature of the immediate post-operative clinical period Epothilone B (EPO906, Patupilone) was a significant predictor of mortality (severe sepsis: OR = 10.5; 95%CI = 24.0-66.0; p < 0.0001, septic shock: OR = 39.8; 95%CI = 6.4-17.5; p < 0.0001). Patients requiring ICU admission (OR = 12.9; 95%CI = 8.8-19.0; p < 0.0001) were also associated with increased mortality rates. Also comorbidities were associated to patient mortality (Malignancy: OR = 3.6; 95%CI = 2.5-15.1; p < 0.0001, immunosuppression: OR = 1.0; 95%CI = 3.2-7.5; p < 0.0001, and serious cardiovascular disease: OR = 4.5; 95%CI = 3.2-6.3, p < 0.0001). According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001) (Table 11), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation: OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001). Table 11 Multivariate analysis: risk factors for occurrence of death during hospitalization Risk factors Odds ratio 95%CI p Age 3.3 2.2-5 <0.0001 Small bowel perforation 27.6 15.9-47.8 <0.0001 Delayed initial intervention 14.6 8.