16 The aim of the current study was to estimate the incidence rates of ICC, NHL overall, and

NHL subtypes in a Y-27632 chemical structure nationwide parous women cohort and to assess their association with chronic HBV infection. CI, confidence interval; EIA, enzyme immunoassay; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; HCV, hepatitis C virus; HR, hazard ratio; IARC, International Agency for Research on Cancer; ICC, intrahepatic cholangiocarcinoma; ICD-O-FT, International Classification of Disease for Oncology, Field Trial Edition; NHL, non-Hodgkin lymphoma; RIA, radioimmunoassay. Three population-based registries were used in this study: the National Hepatitis B Vaccination Registry, the National Cancer Registry, and the National Death Certification Registry. Records for each individual were linked across these registries by use of the national identification number, which is a unique identifier assigned to all residents in Taiwan. The Taiwan

National Hepatitis B Vaccination Registry was established in 1983, serving as the data repository of the national hepatitis B vaccination program.17 Briefly, ≈80% of the pregnant women during the study period in Taiwan attended the recommended APO866 prenatal testing.18, 19 The test results were used to determine a mother’s HBV serostatus, which in turn were used to schedule vaccination for her neonate(s). The National Cancer Registry was established in 1979 and is an ongoing effort that collects information on patient demographics, date at diagnosis, cancer site, morphology, and treatment in Taiwan. The newly diagnosed cases in the registry were reported by the department of medical records in each of the 214 hospitals with more than 50 beds in Taiwan. The completeness and accuracy of the registry are evaluated on a yearly basis; the proportion of death certificate-only

cases was 1.42% for all cancers medchemexpress and the proportion of morphologically verified cases was 90.76% in women.20 All reported cancers were coded using the International Classification of Disease for Oncology, Field Trial Edition (ICD-O-FT) in the National Cancer Registry. The National Death Certification Registry contains information of the date and causes of all deaths in Taiwan.21 Every death is issued a certificate by doctors or a medical official in the district health offices in Taiwan. The registration in the Registry is mandated by Taiwanese law. This study included all parous women recorded in the National Hepatitis B Vaccination Registry whose prenatal HBV seromarkers were tested by enzyme immunoassay (EIA) or radioimmunoassay (RIA) from October 1, 1983 to March 31, 2000, as described.16 After excluding women with missing age at the time of test (N = 446), there were 1,782,401 women included in this analysis. For each woman, her last HBV serostatus, both HBsAg and HBeAg, was used in this analysis.