“The therapeutic strategy in gastric lymphoma has completely changed over the last two decades. This change is mainly characterised by the abandonnement selleck kinase inhibitor of surgery in favour of conservative therapies and the introduction of Helicobacter pylori eradication therapy. It became evident that conservative treatment with radiation and/or chemotherapy is at least as effective
as surgical resection and additionally offers the advantage of stomach preservation and better quality of life. The therapeutic goal is undoubtedly complete remission of the lymphoma as a necessary basis for cure of the disease. Both radiotherapy and chemotherapy have a high curative potential in gastric MALT lymphoma and diffuse large B-cell lymphoma (DLBCL.), respectively. An open question is the additional benefit of radiation following Rituximab-CHOP chemotherapy in DLBCL. In patients with gastric MALT lymphoma of stage I H. pylori eradication offers complete remission rates of up to 80% with excellent long-term prognosis and a real chance of cure. Patients with MALT lymphoma of stage II and those with DLBCL of stage I may also respond to eradication therapy in the individual case. It also emerged recently that
there is no need for any oncological therapy in patients revealing minimal histological residuals after successful H. pylon eradication. A watch-and-wait strategy is the adequate management of this condition.
In summary, therapy of gastric lymphoma is nowadays individualised with lymphoma type, stage, and H. pylori status as the determinants of the choice of treatment. Efficacy and quality of life are
strong arguments for a definite see more conservative approach encompassing H. pylon eradication, radiation and chemotherapy. (C) 2010 Elsevier Ltd. All rights reserved.”
“Background: Infants aged <12 months have the highest 3-MA in vitro rates of complications and death from pertussis of any age group. Factors that increase the risk of pertussis-related death in infants are not well defined.
Methods: The US Multiple Cause-of-Death and Linked Birth/Infant Death databases were used for 1999 to 2004 to examine pertussis-related infant mortality rates and to obtain anonymous records of infants with pertussis listed as a cause of death and of surviving infants. Infant and maternal characteristics present at the time of birth for infants who died with pertussis were compared with those Of Surviving infants.
Results: During 1999 to 2004, 91 infant deaths were reported with pertussis as a cause of death. All infants were 7 months or younger; 58% were age <2 months. The average annual infant mortality rate attributed to pertussis was 3.8 (95% Cl: 3.0-4.6) per 1,000,000 live births, and 13.1 (95% Cl: 9.8-17.1) per 1,000,000 live births for infants aged <2 months. Infant pertussis deaths showed an independent association with birth weight <2500 g, female sex, Apgar score <8, and mother with <12 years education.