Recent genome-wide association studies in COPD revealed the chromosome 4 region near hedgehog interacting PHA-739358 purchase protein (HHIP).
However, these studies were mostly performed in Caucasians, and additional studies in multiple ethnic groups are needed. We investigated genetic associations of HHIP in Korean COPD and control subjects.
MethodsTwo separate case-control studies were performed. Firstly, 139 subjects with COPD and 199 control subjects were selected from the Soonchunhyang University Bucheon Hospital Biobank. Secondly, 219 individuals with COPD were recruited from the Korean Obstructive Lung Disease (KOLD) cohort. The control subjects consisted of 305 smokers or ex-smokers with normal lung function who were registered
in the Korean Genome Epidemiology Study. Associations between COPD susceptibility and single-nucleotide polymorphism (SNP) genotypes were tested by logistic PFTα chemical structure regression. Associations between lung function and SNP genotypes were tested by linear regression.
ResultsIn the first study, the mean forced expiratory volume in 1s (FEV1) of these COPD subjects was 1.32L. None of 15 SNP was significantly associated with COPD susceptibility. However, four SNP associated significantly with FEV1 in subjects with COPD. In the KOLD cohort study, two SNPs (rs11938704 and rs10013495) near HHIP were significantly associated with FEV1 (P=0.0001 and 0.001, respectively) in subjects with COPD.
ConclusionsGenetic JQ-EZ-05 cost variants in HHIP are associated with lung function in subjects with COPD.”
dependent kinase inhibitors p21 and p27 are important regulators of cell cycle progression. To analyze their role in the malignant progression of canine mammary tumors expression levels of p27 and p21 and its major regulator p53 were compared in simple adenomas, adenocarcinomas of the mammary gland and lymph node metastases with normal mammary gland. Laser microdissection of tissue samples and real-time PCR were used for quantification of mRNA expression levels. p21 was overexpressed in adenocarcinomas, whereas adenomas and metastases expressed p21 more heterogeneously. Comparison of p21 expression in adenocarcinomas and their metastases revealed a significant decrease in expression in metastases. In contrast, p27 expression was reduced in the adenocarcinomas but heterogeneously expressed in adenomas and metastases. Taken together the results suggest that loss of p21 overexpression is associated with tumor metastasis while reduced cell cycle inhibition by p27 is associated with malignant progression. (C) 2008 Elsevier Ltd. All rights reserved.”
“Acrodermatitis enteropathica is a rare, autosomal recessive condition which results from impaired zinc absorption in the gastrointestinal tract. We report a 16-month-old female patient with a 7-month history of periorificial and acral skin lesions.