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Neuro Oncol 2006, 76: 23–30 CrossRef 19 Broeke LT, Das

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Neuro Oncol 2006, 76: 23–30.CrossRef 19. Broeke LT, Daschbach E, Thomas EK, Andringa G, Berzofsky Vemurafenib nmr JA: Dendritic cell-induced activation of adaptive and innate antitumor immunity. J Immunol 2003, 171: 5842–5852.PubMed 20. Qin Z, Blankenstein T: CD4+ T cell-mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN-γ GSK461364 purchase receptor expression by nonhematopoietic cells. Immunity 2000, 12: 677–686.CrossRefPubMed 21. Turley EA, Noble PW, Bourguignon LY: Signaling properties of hyaluronan receptors. J Biol Chem 2002, 277: 4589–4592.CrossRefPubMed 22. Patel D, Lahiji A, Patel S, Franklin M, Jimenez X, Hicklin DJ, et al.: Monoclonal antibody cetuximab binds to and down-regulates constitutively activated epidermal growth factor receptor vIII on the cell surface. Anticancer Res 2007, 27: 3355–3366.PubMed Competing interests The authors declare that they have no competing interests. Authors’ contributions Xiao-yi Duan carried out the molecular genetic studies, participated in the sequence alignment and drafted the manuscript. Dong-gang Han carried out the immunoassays and participated in the sequence

alignment. Ming-xin Zhang participated in the design of the study and performed the statistical analysis. Jian-sheng Wang conceived of the study, and participated in its design and coordination. All authors read and approved the final manuscript.”
“Background Cervical carcinoma is a common malignancy Blebbistatin worldwide and its incidence has been increasing gradually. It poses a significant Amylase health problem, especially in regions such as Asia and North America. Despite advances in diagnostic and treatment modalities, the proportion of failed treatments is still significant, with reported rates of 15.6% to 58% [1]. To date, chemotherapy is the mainstay of treatment modalities for cervical carcinoma and cisplatin has proven to be the most effective single cytotoxic agent for the treatment of advanced or recurrent cervical cancer [2]. However, the response rate is about 23%, due to chemoresistance. Therefore, it is necessary to develop a novel strategy to overcome the chemoresistance of cervical carcinoma

and improve clinical efficiency and prognosis. Although the molecular events responsible for the pathogenesis of cervical carcinoma remain to be elucidated, the final common pathway of carcinogenesis appears to be a disruption of the mechanisms involved in the regulation of cell cycle progression, leading to uncontrolled cell proliferation [3]. Critical cellular signaling underlying the regulation of cell cycle progression has been implicated in a number of cancers. With regard to tumorigenesis, it is worth noting that polo-like kinase 1 (PLK-1), a mitotic cyclin-independent serine-threonine kinase that is believed to be involved in the pathogenesis of numerous carcinomas [4–6], has attracted much attention as a potential therapeutic target.

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